This functionality will become available in version 1.4 of ADCI. Quality control (QC) metrics are applied to samples and aberrations. QC issues related to samples are visible in the sample list within the main GUI. Samples which do not meet QC thresholds are marked with an orange or yellow background color in the sample's “Identity” field. Additional QC issues related to aberrations are colored orange and are visible in the “ Fit a curve” and “ Dose Calculator” dialogs.
Every threshold observed during QC procedures can be modified in a dialog accessed by selecting “Settings” in the menu bar, then clicking “Quality Control Thresholds”.
QC issues related to sample image count can be found in the sample list within the main GUI. The “Fit a curve” and “Dose Calculator” dialogs take into account additional “Aberration” QC thresholds. Note manually entering an aberration in either of these dialogs will not generate a QC issue even if the manually entered values do not meet QC thresholds. For a QC issue to be reported, an aberration must be derived from an imported sample. If a sample does not meet either specified image count threshold, this issue will again be reported in the “Fit a curve” and “Dose Calculator” dialogs.
Hover the mouse pointer over the orange or yellow background color of any reported QC issue to display a tooltip reporting which QC threshold was not met. The QC threshold will be displayed alongside the observed value of the sample. If more than one QC threshold was not met, the first failed threshold will appear in the tooltip.
The “Identity” field in the sample list has a background color of orange when a sample does not meet the “Minimum total images” threshold. A background color of yellow is used when a sample does not meet the “Minimum selected images” threshold.
The “Sample Info” field in the “Dose-Response data” list has a background color of orange when an aberration does not meet QC thresholds.
Because calibration curves are generally intended to be used repeatedly over a significant period of time, an additional warning will pop-up after the “OK” button is clicked to notify the user QC issues are present. At this time, you may opt to finish creating the curve anyway, or return to the “Fit a curve” dialog.
The “Name” field in the “DC Frequencies for Dose Estimation” list has a background color of orange when an aberration does not meet QC thresholds.
The “DC Frequency Name” field found in the console after performing dose estimation contains a “~” symbol if a QC issue is present.
A “Quality Control Issue” field is present under the heading “DC Frequency Information” in dose estimation reports. The field contains text describing the specific QC issue observed.